Investigation of disrupted higher-order topology in OCD brain networks revealed by Hodge Laplacian: In this project we apply a Hodge Laplacian topological framework to investigate higher-order interactions in OCD using a large-scale resting-state fMRI dataset from the ENIGMA-OCD consortium (1,024 OCD patients and 1,028 healthy controls across 28 sites worldwide)
Effects of transcranial direct current stimulation (tDCS) on inhibition performance and brain function in obsessive-compulsive disorder (OCD): In this project we use concurrent tDCS-fMRI to investigate the effects of non-invasive brain stimulation on inhibition impairments and their underlying neuronal mechanisms in individuals with OCD. Collaborator: Dr. Götz Berberich
Effects of exoskeleton training on brain structure, brain function and motor performance in stroke patients: In this project we intend to find out more about the effects of an exoskeleton-supported motor training on brain structure, brain function and motor performance in individuals with a middle cerebral artery (MCA) stroke. Collaborator: Prof. Gordon Cheng, Prof. Joachim Hermsdörfer, Prof. Dr. Dirk Sander
Effects of working memory training on brain structure, brain function and general cognition: This project aims at exploring the effects of a longitudinal working memory training on brain structure, brain function and cognitive performance. In addition, by employing multimodal data analyses the project intends to find out more about the association between structural and functional connectivity at the macroscale. Collaborator: Dr. Igor Yakushev, Dr. Claudia von Bastian
Effects of mindfulness training on brain structure, brain function and mental state: We are investigating the effects of mindfulness training on brain structure, brain function and mental state (e.g., attentional performance, perceived stress, tendency towards stress eating). Collaborator: Prof. Jessica Freiherr, Dr. Britta Hölzel, Dr. Alexander Soutschek
Investigating morphometric networks across different psychotic disorders including Early Psychosis and Parkinson’s Psychosis: In this project we explore structural grey matter changes that occur across different psychotic disorders and disease stages. Collaborator: Dr. Franziska Knolle
Decision making in obsessive-compulsive disorder (OCD): We are employing decision making paradigms to investigate the underlying mechanisms of deficits in reward and prediction error processing in individuals with OCD. Collaborator: Dr. Franziska Knolle
We are part of the international ENIGMA OCD working group consisting of OCD experts from all over the world who re-analyze historical MRI data using meta- and mega-analyses.
We are grateful to the following funding sources for supporting our work:
